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Inhibition of infection caused by severe acute respiratory syndrome-associated coronavirus by equine neutralizing antibody in aged mice.

ABSTRACT: The high susceptibility of elderly to severe acute respiratory syndrome-associated coronavirus (SARS-CoV) indicates how crucial it is to protect the elderly by various strategies. Aged BALB/c mice displayed a high susceptibility to SARS-CoV and have been a valuable platform for evaluation of strategies against SARS-CoV infection. In this study, we confirmed the validity of this model using various methods, and verified that equine anti-SARS-CoV F(ab')(2) can prevent aged animals from SARS-CoV infection. In a therapeutic setting, treatment with anti-SARS-CoV F(ab')(2) decreased viral load more than several thousand folds in the lungs. Thus, this antibody should be a potential candidate for treatment of elderly patients suffering from SARS.

SUBMITTER: Zhou L 

PROVIDER: S-EPMC7106264 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature

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Inhibition of infection caused by severe acute respiratory syndrome-associated coronavirus by equine neutralizing antibody in aged mice.

Zhou Lili L   Ni Bing B   Luo Deyan D   Zhao Guangyu G   Jia Zhengcai Z   Zhang Liangyan L   Lin Zhihua Z   Wang Li L   Zhang Songle S   Xing Li L   Li Jintao J   Liang Yunfei Y   Shi Xinfu X   Zhao Tingting T   Zhou Liyun L   Wu Yuzhang Y   Wang Xiliang X  

International immunopharmacology 20061127 3

The high susceptibility of elderly to severe acute respiratory syndrome-associated coronavirus (SARS-CoV) indicates how crucial it is to protect the elderly by various strategies. Aged BALB/c mice displayed a high susceptibility to SARS-CoV and have been a valuable platform for evaluation of strategies against SARS-CoV infection. In this study, we confirmed the validity of this model using various methods, and verified that equine anti-SARS-CoV F(ab')(2) can prevent aged animals from SARS-CoV in  ...[more]

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