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Group IID, IIE, IIF and III secreted phospholipase A2s.

ABSTRACT: Among the 11 members of the secreted phospholipase A2 (sPLA2) family, group IID, IIE, IIF and III sPLA2s (sPLA2-IID, -IIE, -IIF and -III, respectively) are "new" isoforms in the history of sPLA2 research. Relative to the better characterized sPLA2s (sPLA2-IB, -IIA, -V and -X), the enzymatic properties, distributions, and functions of these "new" sPLA2s have remained obscure until recently. Our current studies using knockout and transgenic mice for a nearly full set of sPLA2s, in combination with comprehensive lipidomics, have revealed unique and distinct roles of these "new" sPLA2s in specific biological events. Thus, sPLA2-IID is involved in immune suppression, sPLA2-IIE in metabolic regulation and hair follicle homeostasis, sPLA2-IIF in epidermal hyperplasia, and sPLA2-III in male reproduction, anaphylaxis, colonic diseases, and possibly atherosclerosis. In this article, we overview current understanding of the properties and functions of these sPLA2s and their underlying lipid pathways in vivo.

SUBMITTER: Murakami M 

PROVIDER: S-EPMC7106514 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Group IID, IIE, IIF and III secreted phospholipase A<sub>2</sub>s.

Murakami Makoto M   Miki Yoshimi Y   Sato Hiroyasu H   Murase Remi R   Taketomi Yoshitaka Y   Yamamoto Kei K  

Biochimica et biophysica acta. Molecular and cell biology of lipids 20180831 6

Among the 11 members of the secreted phospholipase A<sub>2</sub> (sPLA<sub>2</sub>) family, group IID, IIE, IIF and III sPLA<sub>2</sub>s (sPLA<sub>2</sub>-IID, -IIE, -IIF and -III, respectively) are "new" isoforms in the history of sPLA<sub>2</sub> research. Relative to the better characterized sPLA<sub>2</sub>s (sPLA<sub>2</sub>-IB, -IIA, -V and -X), the enzymatic properties, distributions, and functions of these "new" sPLA<sub>2</sub>s have remained obscure until recently. Our current studies  ...[more]

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