Dynamic cerebral autoregulation: A marker of post-operative delirium?
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ABSTRACT: OBJECTIVE:We investigated the potential association of cerebral autoregulation (CA) with postoperative delirium (PD), a common complication of cardiac surgery with cardiopulmonary bypass (CPB). METHODS:In patients undergoing coronary artery bypass graft (CABG) surgery with CPB, cerebral blood flow velocity (CBFV) and blood pressure (BP) were continuously recorded during 5-min preoperatively (T1), after 24?h (T2), and 7?days after procedure (T3). Prospective multivariate logistic regression analysis was performed to determine the independent risk factors of PD. Autoregulation index (ARI) was calculated from the CBFV response to a step change in BP derived by transfer function analysis. RESULTS:In 67 patients, mean age 64.3?±?9.5?years, CA was depressed at T2 as shown by values of ARI (3.9?±?1.7), compared to T1 (5.6?±?1.7) and T3 (5.5?±?1.8) (p?
SUBMITTER: Caldas JR
PROVIDER: S-EPMC7106549 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
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