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Serum choline is associated with hepatocellular carcinoma survival: a prospective cohort study.

ABSTRACT: Background:Higher choline and betaine levels have been linked to lower risk of liver cancer, whereas existing data in relation to hepatocellular carcinoma (HCC) prognosis are scarce. Our objective was to examine the associations of the serum choline and betaine with HCC survival. Methods:866 newly diagnosed HCC patients were enrolled in the Guangdong Liver Cancer Cohort. Serum choline and betaine were assessed using high-performance liquid chromatography with online electro-spray ionization tandem mass spectrometry. Liver cancer-specific survival (LCSS) and overall survival (OS) were calculated. Cox proportional hazards models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs). Results:Serum choline levels were associated with better LCSS (T3 vs. T1: HR?=?0.69, 95% CI: 0.51-0.94; P -trend?

SUBMITTER: Liu ZY

PROVIDER: S-EPMC7106561 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Serum choline is associated with hepatocellular carcinoma survival: a prospective cohort study.

Liu Zhao-Yan ZY Yishake Dinuerguli D Fang Ai-Ping AP Zhang Dao-Ming DM Liao Gong-Cheng GC Tan Xu-Ying XY Zhang Yao-Jun YJ Zhu Hui-Lian HL

Nutrition & metabolism 20200330

<h4>Background</h4>Higher choline and betaine levels have been linked to lower risk of liver cancer, whereas existing data in relation to hepatocellular carcinoma (HCC) prognosis are scarce. Our objective was to examine the associations of the serum choline and betaine with HCC survival.<h4>Methods</h4>866 newly diagnosed HCC patients were enrolled in the Guangdong Liver Cancer Cohort. Serum choline and betaine were assessed using high-performance liquid chromatography with online electro-spray ...[more]

PMID: 32256673

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Project description:<p><strong>BACKGROUND & AIMS: </strong>The effectiveness of surveillance for hepatocellular carcinoma (HCC) in patients with cirrhosis is limited, due to inadequate risk stratification and suboptimal performance of current screening modalities.</p><p><strong>METHODS: </strong>We developed a multicenter prospective cohort of patients with cirrhosis undergoing surveillance with MRI and applied global untargeted metabolomics to 612 longitudinal serum samples from 203 patients. Among them, 37 developed HCC during follow-up.</p><p><strong>RESULTS: </strong>We identified 150 metabolites with significant abundance changes in samples collected prior to HCC (Cases) compared to samples from patients who did not develop HCC (Controls). Tauro-conjugated bile acids and gamma-glutamyl amino acids were increased, while acyl-cholines and deoxycholate derivatives were decreased. Seven amino acids including serine and alanine had strong associations with HCC risk, while strong protective effects were observed for N-acetylglycine and glycerophosphorylcholine. Machine learning using the 150 metabolites, age, gender, and PNPLA3 and TMS6SF2 single nucleotide polymorphisms, identified 15 variables giving optimal performance. Among them, N-acetylglycine had the highest AUC in discriminating Cases and Controls. When restricting Cases to samples collected within 1 year prior to HCC (Cases-12M), additional metabolites including microbiota-derived metabolites were identified. The combination of the top six variables identified by machine learning (alpha-fetoprotein, 6-bromotryptophan, N-acetylglycine, salicyluric glucuronide, testosterone sulfate and age) had good performance in discriminating Cases-12M from Controls (AUC 0.88, 95% CI 0.83-0.93). Finally, 23 metabolites distinguished Cases with LI-RADS-3 lesions from Controls with LI-RADS-3 lesions, with reduced abundance of acyl-cholines and glycerophosphorylcholine-related lysophospholipids in Cases.</p><p><strong>CONCLUSIONS: </strong>This study identified N-acetylglycine, amino acids, bile acids and choline-derived metabolites as biomarkers of HCC risk, and microbiota-derived metabolites as contributors to HCC development.</p>

Dataset Information

Serum choline is associated with hepatocellular carcinoma survival: a prospective cohort study.

Publications

Serum choline is associated with hepatocellular carcinoma survival: a prospective cohort study.

Similar Datasets

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