Can metagenomic next-generation sequencing identify the pathogens responsible for culture-negative prosthetic joint infection?

ABSTRACT:

Background

The aims of this study were to (1) evaluate the efficacy and safety of targeted antibiotics for the treatment of culture-negative prosthetic joint infection based on metagenomic next-generation sequencing results and (2) verify the accuracy and reliability of metagenomic next-generation sequencing for identifying pathogens related to culture-negative prosthetic joint infection.

Methods

Ninety-seven consecutive PJI patients, including 27 patients with culture-negative prosthetic joint infection, were treated surgically at our center. Thirteen of the 27 culture-negative prosthetic joint infection patients, who were admitted before June 2017 and treated with empirical antibiotics, comprised the empirical antibiotic group (EA group), and the other 14 patients, who wer

SUBMITTER: Wang C 

PROVIDER: S-EPMC7106575 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature