Expression profile analysis identifies key genes as prognostic markers for metastasis of osteosarcoma.
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ABSTRACT:
SUBMITTER: Guan X
PROVIDER: S-EPMC7106759 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Expression profile analysis identifies key genes as prognostic markers for metastasis of osteosarcoma.
Guan Xiaoqing X Guan Zhiyuan Z Song Chunli C
Cancer cell international 20200330
<h4>Background</h4>OS is the most common malignant tumor of bone which was featured with osteoid or immature bone produced by the malignant cells, and biomarkers are urgently needed to identify patients with this aggressive disease.<h4>Methods</h4>We downloaded gene expression profiles from GEO and TARGET datasets for OS, respectively, and performed WGCNA to identify the key module. Whereafter, functional annotation and GSEA demonstrated the relationships between target genes and OS.<h4>Results< ...[more]
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