Ontology highlight
ABSTRACT:
SUBMITTER: Zhang C
PROVIDER: S-EPMC7107496 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Zhang Chengfei C Yan Yan Y He Hongwang H Wang Li L Zhang Na N Zhang Jie J Huang Hongjun H Wu Nannan N Ren Hua H Qian Min M Liu Mingyao M Du Bing B
Journal of molecular cell biology 20190501 5
Among the most important sensors of extracellular danger signals, purinergic receptors have been demonstrated to play crucial roles in host defense against infection. However, the function of P2 receptors in viral infection has been little explored. Here we demonstrated that P2Y13 and its ligand ADP play an important role in protecting hosts from viral infections. First, we demonstrate that P2Y13, as a typical interferon-stimulated gene, is induced together with extracellular ADP during viral in ...[more]