Unknown

Dataset Information

0

Human bocavirus: prevalence and clinical spectrum at a children's hospital.


ABSTRACT: BACKGROUND:Molecular methods of pathogen discovery have recently led to the description of several new respiratory viruses. Human bocavirus (HBoV), a proposed member of the family Parvoviridae, is one of the most recently described respiratory viruses. Initial reports indicate that HBoV is a common cause of respiratory tract infection in children. METHODS:A total of 1474 nasal scraping specimens collected over a 20-month period were screened by polymerase chain reaction for the presence of HBoV nucleic acid. Positive results were confirmed with a second polymerase chain reaction assay from a different genomic region. The medical records of patients with positive results were reviewed for demographic and clinical data. RESULTS:HBoV DNA was identified in 82 samples (5.6%). The peak rate of HBoV infection occurred during the period of March through May in both 2004 and 2005. Sixty-three percent of infected patients were <12 months of age. The most common symptoms were cough, rhinorrhea, and fever. Other symptoms of interest included diarrhea and a "paroxysmal" cough that was clinically suspected to be caused by Bordetella pertussis. CONCLUSIONS:HBoV DNA is commonly present in children with upper and lower respiratory tract infections. The presence of a pertussis-like cough and diarrhea in association with HBoV infection merits further investigation.

SUBMITTER: Arnold JC 

PROVIDER: S-EPMC7107867 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications

Human bocavirus: prevalence and clinical spectrum at a children's hospital.

Arnold John C JC   Singh Kumud K KK   Spector Stephen A SA   Sawyer Mark H MH  

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20060619 3


<h4>Background</h4>Molecular methods of pathogen discovery have recently led to the description of several new respiratory viruses. Human bocavirus (HBoV), a proposed member of the family Parvoviridae, is one of the most recently described respiratory viruses. Initial reports indicate that HBoV is a common cause of respiratory tract infection in children.<h4>Methods</h4>A total of 1474 nasal scraping specimens collected over a 20-month period were screened by polymerase chain reaction for the pr  ...[more]

Similar Datasets

| S-EPMC7114665 | biostudies-literature
| S-EPMC7173585 | biostudies-literature
2009-01-06 | GSE14286 | GEO
| S-EPMC7199845 | biostudies-literature
| S-EPMC6609429 | biostudies-literature
| PRJDB12572 | ENA
| S-EPMC7774574 | biostudies-literature
| S-EPMC8473146 | biostudies-literature
| S-EPMC5039315 | biostudies-other
| S-EPMC3374421 | biostudies-literature