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Federating Structural Models and Data: Outcomes from A Workshop on Archiving Integrative Structures.


ABSTRACT: Structures of biomolecular systems are increasingly computed by integrative modeling. In this approach, a structural model is constructed by combining information from multiple sources, including varied experimental methods and prior models. In 2019, a Workshop was held as a Biophysical Society Satellite Meeting to assess progress and discuss further requirements for archiving integrative structures. The primary goal of the Workshop was to build consensus for addressing the challenges involved in creating common data standards, building methods for federated data exchange, and developing mechanisms for validating integrative structures. The summary of the Workshop and the recommendations that emerged are presented here.

SUBMITTER: Berman HM 

PROVIDER: S-EPMC7108332 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Federating Structural Models and Data: Outcomes from A Workshop on Archiving Integrative Structures.

Berman Helen M HM   Adams Paul D PD   Bonvin Alexandre A AA   Burley Stephen K SK   Carragher Bridget B   Chiu Wah W   DiMaio Frank F   Ferrin Thomas E TE   Gabanyi Margaret J MJ   Goddard Thomas D TD   Griffin Patrick R PR   Haas Juergen J   Hanke Christian A CA   Hoch Jeffrey C JC   Hummer Gerhard G   Kurisu Genji G   Lawson Catherine L CL   Leitner Alexander A   Markley John L JL   Meiler Jens J   Montelione Gaetano T GT   Phillips George N GN   Prisner Thomas T   Rappsilber Juri J   Schriemer David C DC   Schwede Torsten T   Seidel Claus A M CAM   Strutzenberg Timothy S TS   Svergun Dmitri I DI   Tajkhorshid Emad E   Trewhella Jill J   Vallat Brinda B   Velankar Sameer S   Vuister Geerten W GW   Webb Benjamin B   Westbrook John D JD   White Kate L KL   Sali Andrej A  

Structure (London, England : 1993) 20191125 12


Structures of biomolecular systems are increasingly computed by integrative modeling. In this approach, a structural model is constructed by combining information from multiple sources, including varied experimental methods and prior models. In 2019, a Workshop was held as a Biophysical Society Satellite Meeting to assess progress and discuss further requirements for archiving integrative structures. The primary goal of the Workshop was to build consensus for addressing the challenges involved i  ...[more]

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