Ontology highlight
ABSTRACT:
SUBMITTER: Xiong Y
PROVIDER: S-EPMC7108912 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Xiong Yan Y Wang Liqing L Di Giorgio Eros E Akimova Tatiana T Beier Ulf H UH Han Rongxiang R Trevisanut Matteo M Kalin Jay H JH Cole Philip A PA Hancock Wayne W WW
The Journal of clinical investigation 20200401 4
Foxp3+ Tregs are key to immune homeostasis, but the contributions of various large, multiprotein complexes that regulate gene expression remain unexplored. We analyzed the role in Tregs of the evolutionarily conserved CoREST complex, consisting of a scaffolding protein, Rcor1 or Rcor2, plus Hdac1 or Hdac2 and Lsd1 enzymes. Rcor1, Rcor2, and Lsd1 were physically associated with Foxp3, and mice with conditional deletion of Rcor1 in Foxp3+ Tregs had decreased proportions of Tregs in peripheral lymp ...[more]