Ontology highlight
ABSTRACT:
SUBMITTER: Wu A
PROVIDER: S-EPMC7108919 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Wu Anjui A Cremaschi Paolo P Wetterskog Daniel D Conteduca Vincenza V Franceschini Gian Marco GM Kleftogiannis Dimitrios D Jayaram Anuradha A Sandhu Shahneen S Wong Stephen Q SQ Benelli Matteo M Salvi Samanta S Gurioli Giorgia G Feber Andrew A Pereira Mariana Buongermino MB Wingate Anna Maria AM Gonzalez-Billalebeitia Enrique E De Giorgi Ugo U Demichelis Francesca F Lise Stefano S Attard Gerhardt G
The Journal of clinical investigation 20200401 4
Tumor DNA circulates in the plasma of cancer patients admixed with DNA from noncancerous cells. The genomic landscape of plasma DNA has been characterized in metastatic castration-resistant prostate cancer (mCRPC) but the plasma methylome has not been extensively explored. Here, we performed next-generation sequencing (NGS) on plasma DNA with and without bisulfite treatment from mCRPC patients receiving either abiraterone or enzalutamide in the pre- or post-chemotherapy setting. Principal compon ...[more]