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Engineered cartilage utilizing fetal cartilage-derived progenitor cells for cartilage repair.


ABSTRACT: The aim of this study was to develop a fetal cartilage-derived progenitor cell (FCPC) based cartilage gel through self-assembly for cartilage repair surgery, with clinically useful properties including adhesiveness, plasticity, and continued chondrogenic remodeling after transplantation. Characterization of the gels according to in vitro self-assembly period resulted in increased chondrogenic features over time. Adhesion strength of the cartilage gels were significantly higher compared to alginate gel, with the 2-wk group showing a near 20-fold higher strength (1.8?±?0.15 kPa vs. 0.09?±?0.01 kPa, p?

SUBMITTER: Park DY 

PROVIDER: S-EPMC7109068 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Engineered cartilage utilizing fetal cartilage-derived progenitor cells for cartilage repair.

Park Do Young DY   Min Byoung-Hyun BH   Park So Ra SR   Oh Hyun Ju HJ   Truong Minh-Dung MD   Kim Mijin M   Choi Ja-Young JY   Park In-Su IS   Choi Byung Hyune BH  

Scientific reports 20200331 1


The aim of this study was to develop a fetal cartilage-derived progenitor cell (FCPC) based cartilage gel through self-assembly for cartilage repair surgery, with clinically useful properties including adhesiveness, plasticity, and continued chondrogenic remodeling after transplantation. Characterization of the gels according to in vitro self-assembly period resulted in increased chondrogenic features over time. Adhesion strength of the cartilage gels were significantly higher compared to algina  ...[more]

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