Alternative promoters control UGT2B17-dependent androgen catabolism in prostate cancer and its influence on progression.

ABSTRACT:

Background

Perturbation of the major UGT2B17-dependent androgen catabolism pathway has the potential to affect prostate cancer (PCa) progression. The objective was to evaluate UGT2B17 protein expression in primary tumours in relation to hormone levels, disease characteristics and cancer evolution.

Methods

We conducted an analysis of a high-density prostate tumour tissue microarray consisting of 239 localised PCa cases treated by radical prostatectomy (RP). Cox proportional hazard ratio analysis was used to evaluate biochemical recurrence (BCR), and a linear regression model evaluated variations in circulating hormone levels measured by mass spectrometry. The transcriptome of UGT2B17 in PCa was established by using RNA-sequencing data.

Results

UGT2B17 expression in pri

SUBMITTER: Levesque E 

PROVIDER: S-EPMC7109100 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature