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Evaluation of the peri-implant bone trabecular microstructure changes in short implants with fractal analysis.

ABSTRACT: BACKGROUNDS:This study aimed to evaluate the microstructural changes in the peri-implant bone in patients with short implants in terms of implant survival status by using fractal analysis measurements. RESULTS:Dental panoramic radiographs (DPRs) of 67 patients were examined and included in this study. Fractal analysis and measurement of the crown-implant ratio were performed with ImageJ. The fractal analysis measurement was performed on the DPRs obtained at preoperative (FD0) and in the follow-up periods (after 2 ± 2?weeks (FD1), 2?months ± 2?weeks (FD2), 6?months ± 2?weeks (FD3), and 12?months + (FD4)). A p value < 0.05 was considered statistically significant. Power analyses were conducted for the test results that did not reject null hypothesis. A significant difference was found in the FD1 and FD2 values between the implant survival groups (p < 0.001 and p = 0.023, respectively). The mean FD1 and FD2 values of the success group were significantly higher than those of the failure group. CONCLUSIONS:Fractal analysis is a useful method to measure the trabecular microstructure of bone in non-standardized dental radiographs. The present study has a low power to reject the null hypothesis because of the low number of cases of implant failure. Therefore, further study with a large sample size is warranted. In clinical practice, the survival of implants may be predicted by analyzing fractal dimension of the surrounding trabecular bone of the implants.

SUBMITTER: K?s HC

PROVIDER: S-EPMC7109216 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Evaluation of the peri-implant bone trabecular microstructure changes in short implants with fractal analysis.

Kış Hatice Cansu HC Güleryüz Gürbulak Ayşegül A

International journal of implant dentistry 20200401 1

<h4>Backgrounds</h4>This study aimed to evaluate the microstructural changes in the peri-implant bone in patients with short implants in terms of implant survival status by using fractal analysis measurements.<h4>Results</h4>Dental panoramic radiographs (DPRs) of 67 patients were examined and included in this study. Fractal analysis and measurement of the crown-implant ratio were performed with ImageJ. The fractal analysis measurement was performed on the DPRs obtained at preoperative (FD0) and ...[more]

PMID: 32236773

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Project description:Most previous genetic epidemiology studies within the field of osteoporosis have focused on the genetics of the complex trait areal bone mineral density (aBMD), not being able to differentiate genetic determinants of cortical volumetric BMD (vBMD), trabecular vBMD, and bone microstructural traits. The objective of this study was to separately identify genetic determinants of these bone traits as analysed by peripheral quantitative computed tomography (pQCT). Separate GWA meta-analyses for cortical and trabecular vBMDs were performed. The cortical vBMD GWA meta-analysis (n?=?5,878) followed by replication (n?=?1,052) identified genetic variants in four separate loci reaching genome-wide significance (RANKL, rs1021188, p?=?3.6×10?¹?; LOC285735, rs271170, p?=?2.7×10?¹²; OPG, rs7839059, p?=?1.2×10?¹?; and ESR1/C6orf97, rs6909279, p?=?1.1×10??). The trabecular vBMD GWA meta-analysis (n?=?2,500) followed by replication (n?=?1,022) identified one locus reaching genome-wide significance (FMN2/GREM2, rs9287237, p?=?1.9×10??). High-resolution pQCT analyses, giving information about bone microstructure, were available in a subset of the GOOD cohort (n?=?729). rs1021188 was significantly associated with cortical porosity while rs9287237 was significantly associated with trabecular bone fraction. The genetic variant in the FMN2/GREM2 locus was associated with fracture risk in the MrOS Sweden cohort (HR per extra T allele 0.75, 95% confidence interval 0.60-0.93) and GREM2 expression in human osteoblasts. In conclusion, five genetic loci associated with trabecular or cortical vBMD were identified. Two of these (FMN2/GREM2 and LOC285735) are novel bone-related loci, while the other three have previously been reported to be associated with aBMD. The genetic variants associated with cortical and trabecular bone parameters differed, underscoring the complexity of the genetics of bone parameters. We propose that a genetic variant in the RANKL locus influences cortical vBMD, at least partly, via effects on cortical porosity, and that a genetic variant in the FMN2/GREM2 locus influences GREM2 expression in osteoblasts and thereby trabecular number and thickness as well as fracture risk.

Dataset Information

Evaluation of the peri-implant bone trabecular microstructure changes in short implants with fractal analysis.

Publications

Evaluation of the peri-implant bone trabecular microstructure changes in short implants with fractal analysis.

Similar Datasets

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