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Phytochemical Study on Antioxidant and Antiproliferative Activities of Moroccan Caralluma europaea Extract and Its Bioactive Compound Classes.

ABSTRACT: Background:Caralluma europaea (C. europaea) is a medicinal plant used in Moroccan popular medicine. Objective of the Study. The present work was aimed at identifying the chemical composition and the antioxidant and antiproliferative activities of hydroethanolic and bioactive compound classes of C. europaea) is a medicinal plant used in Moroccan popular medicine. Materials and Methods. The chemical composition was analyzed using HPLC. The antioxidant power was determined using both DPPH and FRAP assays. The antiproliferative activity was effectuated against cancerous cells using WST-1. Results:The chemical analysis showed the presence of bioactive constituents such as quercetin, myricetin, and hesperetin. The polyphenol and flavonoid contents were estimated at 51.42?mg GA/g and 20.06?mg EQ/g, respectively. The EC50 values of FRAP assay of hydroethanolic, flavonoid, saponin, and mucilage extracts were 5.196?mg/ml, 4.537?mg/ml, 3.05?mg/ml, and 6.02?mg/ml, respectively. The obtained IC50 values with the DPPH test were 1.628?mg/ml, 1.05?mg/ml, 1.94?mg/ml, and 9.674?mg/ml, respectively. Regarding MDA-MB-231, saponins were highly effective even with the lowest concentration (15.62??g/ml). The flavonoids decreased the cell viability with IC50 values of 43.62?±?0.06??g/ml). The flavonoids decreased the cell viability with IC50 values of 43.62?±?0.06??g/ml). The flavonoids decreased the cell viability with IC50 values of 43.62?±?0.06?. Conclusion:The present results suggest that C. europaea) is a medicinal plant used in Moroccan popular medicine.

SUBMITTER: Amrati FE

PROVIDER: S-EPMC7109577 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Phytochemical Study on Antioxidant and Antiproliferative Activities of Moroccan Caralluma europaea Extract and Its Bioactive Compound Classes.

Amrati Fatima Ez-Zahra FE Bourhia Mohammed M Slighoua Meryem M Ibnemoussa Samir S Bari Ahmed A Ullah Riaz R Ullah Riaz R Amaghnouje Amal A Di Cristo Francesca F El Mzibri Mohammed M Calarco Anna A Benbacer Laila L Bousta Dalila D

Evidence-based complementary and alternative medicine : eCAM 20200319

<h4>Background</h4>Caralluma europaea (C. europaea) is a medicinal plant used in Moroccan popular medicine. Objective of the Study. The present work was aimed at identifying the chemical composition and the antioxidant and antiproliferative activities of hydroethanolic and bioactive compound classes of C. europaea) is a medicinal plant used in Moroccan popular medicine. Materials and Methods. The chemical composition was analyzed using HPLC. The a ...[more]

PMID: 32256660

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Project description:Sorghum, the fifth most important cereal crop, is a well-adapted cereal to arid/semi-arid regions. Sorghum is known for multiple end-uses as food, feed, fuel, forage, and as source of bioactive compounds that could be used for medical applications. Although the great improvement in the process of sorghum breeding, the average yield of this crop is still very low. Therefore, exploring the genetic diversity in sorghum accessions is a critical step for improving this crop. The main objective of the current work was to study the genetic variation existing in a Moroccan sorghum collection. Indeed, 10 sorghum ecotypes were characterized based on agromorphological descriptors. Both quantitative (25) and qualitative (7) traits revealed variability (p < 0.05) among the studied ecotypes. At the seedling stage, most of the ecotypes showed good to high vigor (70%). However, as the sorghum plants grow, the difference between genotypes become more apparent, especially at the generative phase. For instance, three different panicle shapes have been observed, erect (50%), semi-bent (30%), and bent (20%) with different degree of compactness (20% for loose, semi-compact, and compact panicles, and 30% for semi-loose panicles). In another part of this study, the phytochemical composition and antioxidant activities of the sorghum ecotypes have been determined. The results showed variable total phenolic contents, and total flavonoid contents ranging from 125.86 ± 1.36 to 314.91 ± 3.60 mg GAE/g dw and 114.0 ± 13.2 to 138.5 ± 10.8 (mg catechin equivalent/100 g, dw) respectively, with a differential antioxidant activities as well. These results indicate that for any crop breeding program, it is preferable to take into consideration both morphological and biochemical traits for a better selection of high yielding varieties with high added value compounds. Therefore, the implication of these results in the context of sorghum breeding activities could be a resourceful option for farmers.

Dataset Information

Phytochemical Study on Antioxidant and Antiproliferative Activities of Moroccan Caralluma europaea Extract and Its Bioactive Compound Classes.

Publications

Phytochemical Study on Antioxidant and Antiproliferative Activities of Moroccan <i>Caralluma europaea</i> Extract and Its Bioactive Compound Classes.

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