Ontology highlight
ABSTRACT:
SUBMITTER: Wu C
PROVIDER: S-EPMC7109600 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Wu Chen C Cui Yaqi Y Liu Xiuhua X Zhang Feng F Lu Lin-Yu LY Yu Xiaochun X
Journal of molecular cell biology 20200201 2
p53 is a key transcription factor to regulate gene transcription. However, the molecular mechanism of chromatin-associated p53 on gene transcription remains elusive. Here, using unbiased protein affinity purification, we found that the RNF20/40 complex associated with p53 on the chromatin. Further analyses indicated that p53 mediated the recruitment of the RNF20/40 complex to p53 target gene loci including p21 and PUMA loci and regulated the transcription of p21 and PUMA via the RNF20/40 complex ...[more]