Ontology highlight
ABSTRACT:
SUBMITTER: He M
PROVIDER: S-EPMC7109608 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
He Min M Wu Nan N Leong Man Cheong MC Zhang Weiwei W Ye Zi Z Li Rumei R Huang Jinyang J Zhang Zhaoyun Z Li Lianxi L Yao Xiao X Zhou Wenbai W Liu Naijia N Yang Zhihong Z Dong Xuehong X Li Yintao Y Chen Lili L Li Qin Q Wang Xuanchun X Wen Jie J Zhao Xiaolong X Lu Bin B Yang Yehong Y Wang Qinghua Q Hu Renming R
Journal of molecular cell biology 20200201 2
Chronic inflammation plays a pivotal role in insulin resistance and type 2 diabetes, yet the mechanisms are not completely understood. Here, we demonstrated that serum LPS levels were significantly higher in newly diagnosed diabetic patients than in normal control. miR-145 level in peripheral blood mononuclear cells decreased in type 2 diabetics. LPS repressed the transcription of miR-143/145 cluster and decreased miR-145 levels. Attenuation of miR-145 activity by anti-miR-145 triggered liver in ...[more]