Ontology highlight
ABSTRACT:
SUBMITTER: Hampton-O'Neil LA
PROVIDER: S-EPMC7109712 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Hampton-O'Neil Lea A LA Severn Charlotte E CE Cross Stephen J SJ Gurung Sonam S Nobes Catherine D CD Toye Ashley M AM
Haematologica 20190613 4
Erythropoiesis is one of the most efficient cellular processes in the human body producing approximately 2.5 million red blood cells every second. This process occurs in a bone marrow niche comprised of a central resident macrophage surrounded by differentiating erythroblasts, termed an erythroblastic island. It is not known what initially attracts the macrophage to erythroblasts to form these islands. The ephrin/Eph receptor family are known to regulate heterophilic cell-cell adhesion. We find ...[more]