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Characterization of human metapneumoviruses isolated from patients in North America.

ABSTRACT: Human metapneumovirus (HMPV) was recently identified in The Netherlands and was linked to acute respiratory tract illness. In this study, 11 isolates from 10 patients with respiratory disease from Quebec, Canada, were tested by a reverse-transcriptase polymerase chain reaction based on the fusion protein gene. Identified sequences were consistent with HMPV. The patients were 2 months to 87 years of age (median age, 58 years) and presented with acute respiratory tract illness during the winter season. Sequence studies of the nucleocapsid, fusion, and polymerase genes identified 2 main lineages of HMPV and cocirculation of both lineages during the same year. These findings support a previous finding that HMPV is a human respiratory pathogen that merits further study.

SUBMITTER: Peret TC

PROVIDER: S-EPMC7109943 | biostudies-literature | 2002 Jun

REPOSITORIES: biostudies-literature

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Characterization of human metapneumoviruses isolated from patients in North America.

Peret Teresa C T TC Boivin Guy G Li Yan Y Couillard Michel M Humphrey Charles C Osterhaus Albert D M E AD Erdman Dean D DD Anderson Larry J LJ

The Journal of infectious diseases 20020503 11

Human metapneumovirus (HMPV) was recently identified in The Netherlands and was linked to acute respiratory tract illness. In this study, 11 isolates from 10 patients with respiratory disease from Quebec, Canada, were tested by a reverse-transcriptase polymerase chain reaction based on the fusion protein gene. Identified sequences were consistent with HMPV. The patients were 2 months to 87 years of age (median age, 58 years) and presented with acute respiratory tract illness during the winter se ...[more]

PMID: 12023774

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