Ontology highlight
ABSTRACT:
SUBMITTER: Liu SJ
PROVIDER: S-EPMC7110660 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Liu S John SJ Malatesta Martina M Lien Brian V BV Saha Parna P Thombare Shivani S SS Hong Sung Jun SJ Pedraza Leslie L Koontz Mark M Seo Kyounghee K Horlbeck Max A MA He Daniel D Birk Harjus S HS Jain Miten M Olsen Hugh E HE Akeson Mark M Weissman Jonathan S JS Monje Michelle M Gupta Nalin N Raleigh David R DR Ullian Erik M EM Lim Daniel A DA
Genome biology 20200331 1
<h4>Background</h4>Long non-coding RNAs (lncRNAs) exhibit highly cell type-specific expression and function, making this class of transcript attractive for targeted cancer therapy. However, the vast majority of lncRNAs have not been tested as potential therapeutic targets, particularly in the context of currently used cancer treatments. Malignant glioma is rapidly fatal, and ionizing radiation is part of the current standard-of-care used to slow tumor growth in both adult and pediatric patients. ...[more]