Ontology highlight
ABSTRACT:
SUBMITTER: Pi-Sunyer X
PROVIDER: S-EPMC7111229 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Pi-Sunyer Xavier X Apovian Caroline M CM McElroy Susan L SL Dunayevich Eduardo E Acevedo Lisette M LM Greenway Frank L FL
International journal of obesity (2005) 20190121 10
<h4>Background/objectives</h4>Prolonged-release (PR) naltrexone 32 mg/bupropion 360 mg (NB) is approved for chronic weight management as an adjunct to reduced-calorie diet and increased physical activity. Central nervous system-active medications have the potential to affect mood; therefore, post hoc analysis of clinical trial data was conducted to evaluate psychiatric adverse events (PAEs) and effects on mood of NB therapy versus placebo.<h4>Subjects/methods</h4>Data were pooled from 5 prospect ...[more]