Ontology highlight
ABSTRACT:
SUBMITTER: Vernier M
PROVIDER: S-EPMC7111261 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Vernier Mathieu M Dufour Catherine R CR McGuirk Shawn S Scholtes Charlotte C Li Xiaojing X Bourmeau Guillaume G Kuasne Hellen H Park Morag M St-Pierre Julie J Audet-Walsh Etienne E Giguère Vincent V
Genes & development 20200220 7-8
Excessive reactive oxygen species (ROS) can cause oxidative stress and consequently cell injury contributing to a wide range of diseases. Addressing the critical gaps in our understanding of the adaptive molecular events downstream ROS provocation holds promise for the identification of druggable metabolic vulnerabilities. Here, we unveil a direct molecular link between the activity of two estrogen-related receptor (ERR) isoforms and the control of glutamine utilization and glutathione antioxida ...[more]