Ontology highlight
ABSTRACT:
SUBMITTER: Hamada M
PROVIDER: S-EPMC7111275 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
European journal of medicinal chemistry 20130704
A series of seventeen hitherto unknown ANP analogs bearing the (E)-but-2-enyl aliphatic side chain and modified heterocyclic base such as cytosine and 5-fluorocytosine, 2-pyrazinecarboxamide, 1,2,4-triazole-3-carboxamide or 4-substituted-1,2,3-triazoles were prepared in a straight approach through an olefin acyclic cross metathesis as key synthetic step. All novel compounds were evaluated for their antiviral activities against a large number of DNA and RNA viruses including herpes simplex virus ...[more]