Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B.
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ABSTRACT:
SUBMITTER: Zhao X
PROVIDER: S-EPMC7111318 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Publications
Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B.
Zhao Xin X Zhang Guigen G Liu Sheng S Chen Xiangpeng X Peng Ruchao R Dai Lianpan L Qu Xiao X Li Shihua S Song Hao H Gao Zhengrong Z Yuan Pengfei P Liu Zhiheng Z Li Changyao C Shang Zifang Z Li Yan Y Zhang Meifan M Qi Jianxun J Wang Han H Du Ning N Wu Yan Y Bi Yuhai Y Gao Shan S Shi Yi Y Yan Jinghua J Zhang Yong Y Xie Zhengde Z Wei Wensheng W Gao George F GF
Cell 20190516 6
Enterovirus B (EV-B), a major proportion of the genus Enterovirus in the family Picornaviridae, is the causative agent of severe human infectious diseases. Although cellular receptors for coxsackievirus B in EV-B have been identified, receptors mediating virus entry, especially the uncoating process of echovirus and other EV-B remain obscure. Here, we found that human neonatal Fc receptor (FcRn) is the uncoating receptor for major EV-B. FcRn binds to the virus particles in the "canyon" through i ...[more]
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