The role of the CNR1 gene in schizophrenia: a systematic review including unpublished data.

ABSTRACT:

Objective:

Schizophrenia is a multifactorial disorder. It is known that a combination of extensive multiple common alleles may be involved in its etiology, each contributing with a small to moderate effect, and, possibly, some rare alleles with a much larger effect size. We aimed to perform a systematic review of association studies between schizophrenia (and its subphenotypes) and polymorphisms in the CNR1 gene, which encodes cannabinoid receptors classically implicated in schizophrenia pathophysiology, as well as to present unpublished results of an association study in a Brazilian population.

Methods:

Two reviewers independently searched for eligible studies and extracted outcome data using a structured form. Papers were retrieved from PubMed and ISI Web of Knowledge usin

SUBMITTER: Gouvea ES 

PROVIDER: S-EPMC7111446 | biostudies-literature | 2017 Apr-Jun

REPOSITORIES: biostudies-literature