Ontology highlight
ABSTRACT:
SUBMITTER: Konno H
PROVIDER: S-EPMC7111485 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Konno Hiroyuki H Wakabayashi Masaki M Takanuma Daiki D Saito Yota Y Akaji Kenichi K
Bioorganic & medicinal chemistry 20160129 6
Synthesis of serine derivatives having the essential functional groups for the inhibitor of SARS 3CL protease and evaluation of their inhibitory activities using SARS 3CL R188I mutant protease are described. The lead compounds, functionalized serine derivatives, were designed based on the tetrapeptide aldehyde and Bai's cinnamoly inhibitor, and additionally performed with simulation on GOLD softwear. Structure activity relationship studies of the candidate compounds were given reasonable inhibit ...[more]