Ontology highlight
ABSTRACT:
SUBMITTER: Sakai Y
PROVIDER: S-EPMC7111695 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Sakai Yusuke Y Kawachi Kengo K Terada Yutaka Y Omori Hiroko H Matsuura Yoshiharu Y Kamitani Wataru W
Virology 20170721
Infection with coronavirus rearranges the host cell membrane to assemble a replication/transcription complex in which replication of the viral genome and transcription of viral mRNA occur. Although coexistence of nsp3 and nsp4 is known to cause membrane rearrangement, the mechanisms underlying the interaction of these two proteins remain unclear. We demonstrated that binding of nsp4 with nsp3 is essential for membrane rearrangement and identified amino acid residues in nsp4 responsible for the i ...[more]