Ontology highlight
ABSTRACT:
SUBMITTER: Zhang C
PROVIDER: S-EPMC7111710 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Zhang Can C Lu Long-Feng LF Li Zhuo-Cong ZC Zhou Xiao-Yu XY Zhou Yu Y Chen Dan-Dan DD Li Shun S Zhang Yong-An YA
Fish & shellfish immunology 20200204
Grass carp reovirus (GCRV) is an efficient pathogen causing high mortality in grass carp, meanwhile, fish interferon (IFN) is a powerful cytokine enabling host cells to establish an antiviral state; therefore, the strategies used by GCRV to escape the cellular IFN response need to be investigated. Here, we report that GCRV VP56 inhibits host IFN production by degrading the transcription factor IFN regulatory factor 7 (IRF7). First, overexpression of VP56 inhibited the IFN production induced by t ...[more]