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Host single-nucleotide polymorphisms and altered responses to inactivated influenza vaccine.

ABSTRACT: We analyzed the relationship between host gene polymorphisms and responses in recipients of inactivated influenza vaccine, who were classified into poor, normal, or adverse response groups. The frequency of the mannose-binding lectin-2 codon 54 allele was significantly different among the 3 types of responders, with a decreased odds ratio for the development of poor or adverse responses (P=.033). There was no statistical relationship between responses and either tumor necrosis factor- alpha or interleukin (IL)-10 promoter polymorphisms among the 3 response groups. When poor and normal responses were combined, the -1082 A allele in the IL-10 promoter conferred a significantly decreased risk of the development of adverse responses (P=.041). These data indicate that host polymorphisms play a role in determining responses to influenza vaccine.

SUBMITTER: Tang YW

PROVIDER: S-EPMC7111848 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature

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Host single-nucleotide polymorphisms and altered responses to inactivated influenza vaccine.

Tang Yi-Wei YW Li Haijing H Wu Huiyun H Shyr Yu Y Edwards Kathryn M KM

The Journal of infectious diseases 20070829 7

We analyzed the relationship between host gene polymorphisms and responses in recipients of inactivated influenza vaccine, who were classified into poor, normal, or adverse response groups. The frequency of the mannose-binding lectin-2 codon 54 allele was significantly different among the 3 types of responders, with a decreased odds ratio for the development of poor or adverse responses (P=.033). There was no statistical relationship between responses and either tumor necrosis factor- alpha or i ...[more]

PMID: 17763324

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Host single-nucleotide polymorphisms and altered responses to inactivated influenza vaccine.

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Host single-nucleotide polymorphisms and altered responses to inactivated influenza vaccine.

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