Ontology highlight
ABSTRACT:
SUBMITTER: Redondo N
PROVIDER: S-EPMC7111898 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Virology 20130717 1-2
High throughput screening has rendered new inhibitors of eukaryotic protein synthesis. One such molecule, 4EGI-1 has been reported to selectively block the initiation factor eIF4E. We have investigated the action of this inhibitor on translation directed by several viral mRNAs which, in principle, do not utilize eIF4E. We found that 4EGI-1 inhibits translation directed by poliovirus IRES, in rabbit reticulocyte lysates, to a similar extent as capped mRNA. Moreover, 4EGI-1 inhibits translation dr ...[more]