Ontology highlight
ABSTRACT:
SUBMITTER: Gao F
PROVIDER: S-EPMC7111940 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Gao Fei F Yao Huochun H Lu Jiaqi J Wei Zuzhang Z Zheng Haihong H Zhuang Jinshan J Tong Guangzhi G Yuan Shishan S
Virology 20130301 1
The 5' untranslated region (UTR) is believed to be vital for the replication of porcine reproductive and respiratory syndrome virus (PRRSV), yet its functional mechanism remains largely unknown. In this study, to define the cis-acting elements for viral replication and infectivity, The 5' UTR swapping chimeric clones pTLV8 and pSHSP5 were constructed based on two different genotypes full-length infectious cDNA clone pAPRRS and pSHE backbones. Between them, vTLV8 could be rescued from pTLV8 and h ...[more]