Ontology highlight
ABSTRACT:
SUBMITTER: Gartrell-Corrado RD
PROVIDER: S-EPMC7112471 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Gartrell-Corrado Robyn D RD Chen Andrew X AX Rizk Emanuelle M EM Marks Douglas K DK Bogardus Margaret H MH Hart Thomas D TD Silverman Andrew M AM Bayan Claire-Audrey Y CY Finkel Grace G GG Barker Luke W LW Komatsubara Kimberly M KM Carvajal Richard D RD Horst Basil A BA Chang Rui R Monod Anthea A Rabadan Raul R Saenger Yvonne M YM
Cancer research 20200116 5
Patients with resected stage II-III melanoma have approximately a 35% chance of death from their disease. A deeper understanding of the tumor immune microenvironment (TIME) is required to stratify patients and identify factors leading to therapy resistance. We previously identified that the melanoma immune profile (MIP), an IFN-based gene signature, and the ratio of CD8<sup>+</sup> cytotoxic T lymphocytes (CTL) to CD68<sup>+</sup> macrophages both predict disease-specific survival (DSS). Here, w ...[more]