Genomic organization and adaptive evolution of IGHC genes in marine mammals.
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ABSTRACT:
SUBMITTER: Li L
PROVIDER: S-EPMC7112648 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Publications
Genomic organization and adaptive evolution of IGHC genes in marine mammals.
Li Lili L Rong Xinghua X Li Guiting G Wang Yingying Y Chen Bingyao B Ren Wenhua W Yang Guang G Xu Shixia S
Molecular immunology 20180526
Immunoglobulins are important elements of the adaptive immune system that bind to an immense variety of microbial antigens to neutralize infectivity and specify effector functions. In the present study, the immunoglobulin heavy chain constant region (IGHC) genes from marine mammals were identified and compared with those of their terrestrial relatives to explore their genomic organization and evolutionary characteristics. The genomic organization of marine mammal IGHC genes was shown to be conse ...[more]
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