Ontology highlight
ABSTRACT:
SUBMITTER: de Ruiter EJ
PROVIDER: S-EPMC7113229 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
de Ruiter Emma J EJ de Roest Reinout H RH Brakenhoff Ruud H RH Leemans C René CR de Bree Remco R Terhaard Chris H J CHJ Willems Stefan M SM
Cancer immunology, immunotherapy : CII 20200124 4
<h4>Aim</h4>This study aimed to evaluate the presence and prognostic value of tumor-infiltrating T cells in the tumor epithelium in advanced stage, HPV-negative head and neck squamous cell carcinoma (HNSCC) patients treated with primary chemoradiotherapy using digital pathology.<h4>Methods</h4>Pre-treatment biopsies from 80 oropharyngeal, 52 hypopharyngeal, and 29 laryngeal cancer patients were collected in a tissue microarray (TMA) and immunohistochemically stained for T-cell markers CD3, CD4, ...[more]