Cerebrospinal beta-amyloid peptides(1-40) and (1-42) in severe preeclampsia and HELLP syndrome - a pilot study.
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ABSTRACT:
SUBMITTER: Lederer W
PROVIDER: S-EPMC7113242 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Publications
Cerebrospinal beta-amyloid peptides(1-40) and (1-42) in severe preeclampsia and HELLP syndrome - a pilot study.
Lederer Wolfgang W Schaffenrath Helene H Alomar-Dominguez Cristina C Thaler Julia J Fantin Raffaella R Dostal Lucie L Putz Guenther G Humpel Christian C
Scientific reports 20200401 1
During pregnancy, substantial alterations in cerebral plasticity, vascular remodeling and neuronal growth occur in the maternal brain. We investigated whether concentrations of selected neurodiagnostic biomarkers in the cerebrospinal fluid of women with preeclampsia/HELLP syndrome differ from those in healthy controls using enzyme-linked immunosorbent assay technique. We found that tau protein concentrations (p = 0.016) and phospho-tau/tau ratio (p < 0.001) in cerebrospinal fluid were significan ...[more]
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