Ontology highlight
ABSTRACT:
SUBMITTER: Atlasi Y
PROVIDER: S-EPMC7113317 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Nature communications 20200401 1
Translational control plays a central role in regulation of gene expression and can lead to significant divergence between mRNA- and protein-abundance. Here, we used genome-wide approaches combined with time-course analysis to measure the mRNA-abundance, mRNA-translation rate and protein expression during the transition of naïve-to-primed mouse embryonic stem cells (ESCs). We find that the ground state ESCs cultured with GSK3-, MEK-inhibitors and LIF (2iL) display higher ribosome density on a se ...[more]