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Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells.

ABSTRACT: The recent Zika virus (ZIKV) outbreak, which mainly affected Brazil and neighbouring states, demonstrated the paucity of information concerning the epidemiology of several flaviruses, but also highlighted the lack of available agents with which to treat such emerging diseases. Here, we show that heparin, a widely used anticoagulant, while exerting a modest inhibitory effect on Zika Virus replication, fully prevents virus-induced cell death of human neural progenitor cells (NPCs).

SUBMITTER: Ghezzi S

PROVIDER: S-EPMC7113768 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells.

Ghezzi Silvia S Cooper Lynsay L Rubio Alicia A Pagani Isabel I Capobianchi Maria Rosaria MR Ippolito Giuseppe G Pelletier Julien J Meneghetti Maria Cecilia Z MCZ Lima Marcelo A MA Skidmore Mark A MA Broccoli Vania V Yates Edwin A EA Vicenzi Elisa E

Antiviral research 20170105

The recent Zika virus (ZIKV) outbreak, which mainly affected Brazil and neighbouring states, demonstrated the paucity of information concerning the epidemiology of several flaviruses, but also highlighted the lack of available agents with which to treat such emerging diseases. Here, we show that heparin, a widely used anticoagulant, while exerting a modest inhibitory effect on Zika Virus replication, fully prevents virus-induced cell death of human neural progenitor cells (NPCs). ...[more]

PMID: 28063994

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