Ontology highlight
ABSTRACT:
SUBMITTER: Coutard B
PROVIDER: S-EPMC7114094 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Antiviral research 20200210
In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its ...[more]