Ontology highlight
ABSTRACT:
SUBMITTER: Ding X
PROVIDER: S-EPMC7114107 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Ding Xianting X Krutzik Peter O PO Ghaffari Amir Ali AA Zhaozhi Yixiu Y Miranda Daniel D Cheng Genhong G Ho Chih-Ming CM Nolan Garry P GP Sanchez David Jesse DJ
Antiviral research 20190909
As antiviral drug resistance develops and new viruses emerge there is a pressing need to develop strategies to rapidly develop antiviral therapeutics. Here we use phospho-specific flow cytometry to assess perturbations of many different cellular signaling pathways during treatment with drug combinations that are highly effective in blocking Herpes simplex virus type 1 (HSV-1) infection. We discovered two antiviral drug combinations act on distinct signaling pathways, either STAT1 or S6 phosphory ...[more]