Ontology highlight
ABSTRACT:
SUBMITTER: Wang S
PROVIDER: S-EPMC7114441 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Virus research 20080612 1-2
Cell entry of severe acute respiratory syndrome coronavirus (SARS-CoV) is mediated by the viral spike (S) protein. Amino acids 319-510 on the S protein have been mapped as the receptor-binding domain (RBD), which mediates binding to the SARS-CoV receptor angiotensin converting enzyme 2 (ACE2) on SARS-CoV susceptible cells. In this study, we expressed a fusion protein containing the human codon-optimized RBD of the SARS-CoV spike protein linked to the Fc portion of human IgG1 (named RBD-Fc) in HE ...[more]