Ontology highlight
ABSTRACT:
SUBMITTER: Wu A
PROVIDER: S-EPMC7114542 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Wu Andong A Wang Yi Y Zeng Cong C Huang Xingyu X Xu Shan S Su Ceyang C Wang Min M Chen Yu Y Guo Deyin D
Virus research 20150531
Coronavirus 3C-like protease (3CLpro) is responsible for the cleavage of coronaviral polyprotein 1a/1ab (pp1a/1ab) to produce the mature non-structural proteins (nsps) of nsp4-16. The nsp5 of the newly emerging Middle East respiratory syndrome coronavirus (MERS-CoV) was identified as 3CLpro and its canonical cleavage sites (between nsps) were predicted based on sequence alignment, but the cleavability of these cleavage sites remains to be experimentally confirmed and putative non-canonical cleav ...[more]