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Formation of Fine Particles from Curcumin/PVP by the Supercritical Antisolvent Process with a Coaxial Nozzle.

ABSTRACT: The production of fine particles via the supercritical carbon dioxide (SC-CO2) antisolvent process was carried out. The experiments were conducted at temperatures of 40-60 °C and pressures of 8-12 MPa with a 15 mL min-1 carbon dioxide (CO2) and 0.5 mL min-1 feed solution flow rate. As a feed solution, the curcumin and the polyvinylpyrrolidone (PVP) powder were dissolved in acetone and ethanol at concentrations of 1.0 mg mL-1 and 2.0-4.0% in weight, respectively. Scanning electron microscopy (SEM) images described that most of the precipitated particle products have spherical morphologies with a size of less than 1 ?m. The Fourier transform infrared spectroscopy (FT-IR) spectra exhibited that the curcumin structural properties did not shift after the SC-CO2 antisolvent process. Moreover, the PVP addition in the curcumin particle products can enhance the curcumin dissolution in distilled water significantly.

SUBMITTER: Machmudah S

PROVIDER: S-EPMC7114885 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Formation of Fine Particles from Curcumin/PVP by the Supercritical Antisolvent Process with a Coaxial Nozzle.

Machmudah Siti S Winardi Sugeng S Wahyudiono Kanda Hideki H Goto Motonobu M

ACS omega 20200320 12

The production of fine particles via the supercritical carbon dioxide (SC-CO2) antisolvent process was carried out. The experiments were conducted at temperatures of 40-60 °C and pressures of 8-12 MPa with a 15 mL min-1 carbon dioxide (CO2) and 0.5 mL min-1 feed solution flow rate. As a feed solution, the curcumin and the polyvinylpyrrolidone (PVP) powder were dissolved in acetone and ethanol at concentrations of 1.0 mg mL-1 and 2.0-4.0% in ...[more]

PMID: 32258906

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