Ontology highlight
ABSTRACT:
SUBMITTER: Simonson AW
PROVIDER: S-EPMC7115131 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Simonson Andrew W AW Lawanprasert Atip A Goralski Tyler D P TDP Keiler Kenneth C KC Medina Scott H SH
Nanomedicine : nanotechnology, biology, and medicine 20181103
We report the design, synthesis and efficacy of a new class of gel-like nano-carrier, or 'nanogel', prepared via templated electrostatic assembly of anionic hyaluronic acid (HA) polysaccharides with the cationic peptide amphiphile poly-L-lysine (PLL). Small molecules and proteins present during nanogel assembly become directly encapsulated within the carrier and are precisely released by tuning the nanogel HA:PLL ratio to control particle swelling. Remarkably, nanogels exhibit versatile and comp ...[more]