Redox-Active Drug, MnTE-2-PyP⁵⁺, Prevents and Treats Cardiac Arrhythmias Preserving Heart Contractile Function.

ABSTRACT:

Background

Cardiomyopathies remain among the leading causes of death worldwide, despite all efforts and important advances in the development of cardiovascular therapeutics, demonstrating the need for new solutions. Herein, we describe the effects of the redox-active therapeutic Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, AEOL10113, BMX-010 (MnTE-2-PyP⁵⁺), on rat heart as an entry to new strategies to circumvent cardiomyopathies.

Methods

Wistar rats weighing 250-300 g were used in both in vitro and in vivo experiments, to analyze intracellular Ca²⁺ dynamics, L-type Ca²⁺ currents, Ca²⁺ spark frequency, intracellular reactive oxygen species (ROS) levels, and cardiomyocyte and cardiac contractil

SUBMITTER: Barbosa AM 

PROVIDER: S-EPMC7115175 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature