Ontology highlight
ABSTRACT:
SUBMITTER: Simpson MJ
PROVIDER: S-EPMC7115235 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Simpson Matthew J MJ Baker Ruth E RE Vittadello Sean T ST Maclaren Oliver J OJ
Journal of the Royal Society, Interface 20200304 164
We examine the practical identifiability of parameters in a spatio-temporal reaction-diffusion model of a scratch assay. Experimental data involve fluorescent cell cycle labels, providing spatial information about cell position and temporal information about the cell cycle phase. Cell cycle labelling is incorporated into the reaction-diffusion model by treating the total population as two interacting subpopulations. Practical identifiability is examined using a Bayesian Markov chain Monte Carlo ...[more]