Ontology highlight
ABSTRACT:
SUBMITTER: Wu F
PROVIDER: S-EPMC7115516 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Wu Fei F Fan Xingjuan X Yue Yan Y Xiong Sidong S Dong Chunsheng C
Vaccine 20140527 31
Recombinant vesicular stomatitis virus (VSV) is widely used as a vaccine platform. However, the capacity of VSV-based vaccines to induce mucosal immunity has not been fully investigated. In the present study, a recombinant VSV expressing coxsackievirus B3 (CVB3) major immunogen VP1 has been generated and the immune protection elicited by VSV-VP1 was evaluated. We demonstrated that intranasal delivery of VSV-VP1 can induce a potent antigen-specific mucosal immune response as well as a systemic im ...[more]