Ontology highlight
ABSTRACT:
SUBMITTER: Czub M
PROVIDER: S-EPMC7115540 | biostudies-literature | 2005 Mar
REPOSITORIES: biostudies-literature
Czub Markus M Weingartl Hana H Czub Stefanie S He Runtao R Cao Jingxin J
Vaccine 20050301 17-18
Severe acute respiratory syndrome (SARS) caused by a newly identified coronavirus (SARS-CoV) remains a threat to cause epidemics as evidenced by recent sporadic cases in China. In this communication, we evaluated the efficacy and safety of two SARS vaccine candidates based on the recombinant modified vaccinia Ankara (MVA) expressing SARS-CoV spike or nucleocapsid proteins in ferrets. No clinical signs were observed in all the ferrets challenged with SARS-CoV. On the other hand, vaccination did n ...[more]