Ontology highlight
ABSTRACT:
SUBMITTER: Valent P
PROVIDER: S-EPMC7115849 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Pathobiology : journal of immunopathology, molecular and cellular biology 20180601 1
Various myeloid neoplasms, including the myelodysplastic syndromes (MDS), bear a certain risk of progression to secondary acute myeloid leukemia (sAML). The evolution from low-risk to high-risk MDS and finally to sAML suggests that leukemogenesis is a multistep process. However, even before an overt neoplasm, such as an MDS, develops, "prediagnostic" clonal conditions may be identified. With the advent of large-scale genomic screens, such conditions may be detected quite frequently and early in ...[more]