Terminating G-Protein Coupling: Structural Snapshots of GPCR-β-Arrestin Complexes.
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ABSTRACT:
SUBMITTER: Chaturvedi M
PROVIDER: S-EPMC7115862 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
Terminating G-Protein Coupling: Structural Snapshots of GPCR-β-Arrestin Complexes.
Chaturvedi Madhu M Maharana Jagannath J Shukla Arun K AK
Cell 20200312 6
β-arrestins (βarrs) play multifaceted roles in the signaling and regulation of G-protein-coupled receptors (GPCRs) including their desensitization and endocytosis. Recently determined cryo-EM structures of two different GPCRs in complex with βarr1 provide the first glimpse of GPCR-βarr engagement and a structural framework to understand their interaction. ...[more]
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