Sodium homeostasis in the tumour microenvironment.

ABSTRACT: The concentration of sodium ions (Na⁺) is raised in solid tumours and can be measured at the cellular, tissue and patient levels. At the cellular level, the Na⁺ gradient across the membrane powers the transport of H⁺ ions and essential nutrients for normal activity. The maintenance of the Na⁺ gradient requires a large proportion of the cell's ATP. Na⁺ is a major contributor to the osmolarity of the tumour microenvironment, which affects cell volume and metabolism as well as immune function. Here, we review evidence indicating that Na⁺ handling is altered in tumours, explore our current understanding of the mechanisms that may underlie these alterations and consider the potential consequences for cancer progression. Dysregula

SUBMITTER: Leslie TK 

PROVIDER: S-EPMC7115894 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature