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Sodium homeostasis in the tumour microenvironment.

ABSTRACT: The concentration of sodium ions (Na+) is raised in solid tumours and can be measured at the cellular, tissue and patient levels. At the cellular level, the Na+ gradient across the membrane powers the transport of H+ ions and essential nutrients for normal activity. The maintenance of the Na+ gradient requires a large proportion of the cell's ATP. Na+ is a major contributor to the osmolarity of the tumour microenvironment, which affects cell volume and metabolism as well as immune function. Here, we review evidence indicating that Na+ handling is altered in tumours, explore our current understanding of the mechanisms that may underlie these alterations and consider the potential consequences for cancer progression. Dysregulated Na+ balance in tumours may open opportunities for new imaging biomarkers and re-purposing of drugs for treatment.

SUBMITTER: Leslie TK

PROVIDER: S-EPMC7115894 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Sodium homeostasis in the tumour microenvironment.

Leslie Theresa K TK James Andrew D AD Zaccagna Fulvio F Grist James T JT Deen Surrin S Kennerley Aneurin A Riemer Frank F Kaggie Joshua D JD Gallagher Ferdia A FA Gilbert Fiona J FJ Brackenbury William J WJ

Biochimica et biophysica acta. Reviews on cancer 20190723 2

The concentration of sodium ions (Na+) is raised in solid tumours and can be measured at the cellular, tissue and patient levels. At the cellular level, the Na+ gradient across the membrane powers the transport of H+ ions and essential nutrients for normal activity. The maintenance of the Na+ gradient requires a large proportion of the cell's ATP. Na+ is a major contributor to the osmolarity of the tumour microenvironment, which affects cell ...[more]

PMID: 31348974

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